This is especially true when you’re only using hydrocortisone for a short period of time. Usually, these side effects are mild and go away on their own. Hydrocortisone’s most common side effects occur on the skin in the areas where it’s applied.
Both types of hydrocortisone cream are generally safe and effective, but they can sometimes cause side effects. It can treat skin conditions like inflammation, rashes, and itching as both an over-the-counter (OTC) and prescription-only product. Hydrocortisone cream is a common topical corticosteroid medication.